I had the plan to keep some people and interested readers up-to-date regarding my plan to do something else. But as it is in life…you have to set priorities and to do more important things, which normally need a lot of time. That´s why there was no new post in the last four months. Now I had to change my priorities again and will publish some information about the last months. Hopefully u enjoy reading something about my intentions to do the things I did and the experience I gathered in this interesting time.
– KaeptnFuture –
…..within february and march 2012 I really got very close to the total synthesis of my target molecule. I had to run through three synthetic strategies regarding the last steps. Changing the functional groups implemented in the precursor should give me the final product. Unfortunately it was not possible to isolate the natural product in the end, although I could already detect the molecular mass in LC-MS and HRMS-ESI already. I had a crude product mixture in hands which I could not purify neither by simple column chromatography nor by more advanced HPL-Chromatography. On the other hand my results are valuable as I could develop a dependable strategy to build up necessary precursors.
Hopefully at some point people will make use of my laboratory experience and my results so far. In my opinion the synthetic strategy I was following is superior to other strategies I found so far. With my reactions I can more or less easily provdide precursors in a convergent fashion.
What my synthesis was about, I will tell you in some more detailed posts.
Stay tuned 🙂